Catalytic enantioselective synthesis of 2-aryl-chromenes.
نویسندگان
چکیده
An enantioselective Pd-catalyzed 6-endo-trig reaction for the synthesis of 2-aryl-chromenes has been developed. A systematic optimization of a TADDOL-derived ligand set resulted in the identification of a novel monodentate phosphoramidite-palladium catalyst that accesses 2-aryl-2H-chromenes with high yield and enantioselectivity under mild conditions. The products obtained from this method can be transformed into biologically active compounds through functionalization of the chromene alkene.
منابع مشابه
Catalytic Synthesis of 2H‐Chromenes
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عنوان ژورنال:
- Chemical science
دوره 5 6 شماره
صفحات -
تاریخ انتشار 2014